Related Experiment Video

Updated: Jun 10, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Isolated group B streptococcal endogenous endophthalmitis simulating retinoblastoma or persistent fetal vasculature

Emily A McCourt1, Eric M Hink, Vikram D Durairaj

  • 1Rocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado-Denver, Aurora, CO 80045, USA.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|July 20, 2010
PubMed

Insights

Group B streptococcus (GBS) can cause severe neonatal infections. This report details a rare GBS-induced endophthalmitis in a newborn that mimicked retinoblastoma, leading to eye removal.

Area of Science:

  • Ophthalmology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Group B streptococcus (GBS) is a significant cause of neonatal infections like meningitis, sepsis, and pneumonia.
  • Endogenous endophthalmitis is a rare but serious complication of GBS infection in neonates.

Observation:

  • This study describes the second reported case of GBS endogenous endophthalmitis in a healthy newborn.
  • The presented case is the first instance of GBS endophthalmitis in a neonate that clinically resembled retinoblastoma.

Findings:

  • Group B streptococcus was identified as the causative agent of endogenous endophthalmitis.
  • The neonatal endophthalmitis presented with symptoms mimicking retinoblastoma, a pediatric eye cancer.
  • The affected eye required enucleation due to the severity of the infection and misdiagnosis.

Implications:

  • Highlights the importance of considering GBS as a potential cause of neonatal endophthalmitis, even in seemingly healthy infants.
  • Emphasizes the diagnostic challenge posed by GBS endophthalmitis mimicking retinoblastoma, potentially delaying appropriate treatment.
  • Underscores the severe consequences of delayed diagnosis and treatment, including the need for enucleation.

More Related Videos

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...