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Updated: Jun 10, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Venous thrombosis and pulmonary embolus in pediatric patients with large upper extremity venous malformations
Scott N Oishi1, Marybeth Ezaki
1Department of Hand Surgery, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA. scott.oishi@tsrh.org
Insights
Large venous malformations pose serious risks, including deep venous thrombosis and pulmonary emboli, especially in children. Early education on these life-threatening complications is crucial for patients and families.
Area of Science:
- Vascular Surgery
- Pediatric Medicine
- Hematology
Background:
- Venous malformations are congenital vascular anomalies.
- Large venous malformations are associated with significant morbidity.
- Current treatment strategies lack consensus.
Observation:
- Three preadolescent patients with large upper extremity venous malformations were studied.
- All three patients developed deep venous thrombosis.
- Two patients experienced pulmonary emboli, with one fatality.
Findings:
- Large upper extremity venous malformations can lead to life-threatening thrombotic events.
- Deep venous thrombosis and pulmonary emboli are significant risks.
- Preadolescent patients are particularly vulnerable.
Implications:
- Increased awareness of thrombotic risks associated with venous malformations is necessary.
- Patient and family education regarding potential sequelae is imperative.
- Further research into optimal management strategies for large venous malformations is warranted.
Abstract:
Patients with large venous malformations are at risk for deep venous thrombosis and pulmonary embolus. Currently, there is no general consensus on the proper treatment for these patients. We present 3 preadolescent patients with large upper extremity venous malformations, who developed deep venous thrombosis; 2 had documented pulmonary emboli, one of which was fatal. It is imperative that patients and families be educated regarding the potential life-threatening sequelae that may be associated with these large vascular malformations.
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