Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Mesenchymal Stromal Cell Immune Suppression Using Live Imaging in a Three-Dimensional Microfluidic Device.

ACS biomaterials science & engineering·2026
Same author

A microgel bone marrow model of mesenchymal stromal cell paracrine signaling supporting hematopoietic stem cell retention.

Acta biomaterialia·2026
Same author

Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets.

bioRxiv : the preprint server for biology·2026
Same author

Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices.

Science advances·2026
Same author

Bone marrow-derived mesenchymal stromal cells yield greater pain relief and tissue protection than umbilical cord tissue-derived cells in a surgically induced instability model of osteoarthritis.

Osteoarthritis and cartilage·2026
Same author

Professor Xingdong Zhang Special Issue.

Tissue engineering. Part A·2026

Related Experiment Video

Updated: Jun 10, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Engineering more than a cell: vascularization strategies in tissue engineering.

Edward A Phelps1, Andrés J García

  • 1Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA.

Current Opinion in Biotechnology
|July 20, 2010
PubMed
Summary

Developing engineered tissues requires robust vascularization strategies. Recent advances in growth factors, cell transplantation, smart biomaterials, and fabrication techniques show promise for improving tissue perfusion and host integration.

More Related Videos

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Engineered tissue performance is limited by insufficient vascularization and perfusion.
  • Lack of robust vascular networks hinders host integration of engineered tissues.

Purpose of the Study:

  • To review recent developments in vascularization strategies for tissue engineering.
  • To highlight advancements in promoting vascularization and tissue perfusion.

Main Methods:

  • Review of current strategies including growth factor signaling and delivery.
  • Analysis of cell transplantation and bioactive smart matrix materials.
  • Examination of directed fabrication techniques for vascular network formation.

Main Results:

  • Synergistic and engineered bioactive systems demonstrate robust host vascular responses in vivo.
  • Current techniques show potential for improving vascularization in engineered tissues.
  • Advancements in materials and fabrication enhance tissue perfusion.

Conclusions:

  • Refinement of existing and development of new vascularization technologies are crucial.
  • Combining vascularization techniques with functional repair models is key for metabolically active tissues.
  • Future research should focus on applications in relevant disease states.