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Related Experiment Videos

Ascorbic acid supplements in patients receiving chronic peritoneal dialysis.

G M Shah1, E A Ross, A Sabo

  • 1Nephrology Section, Veterans Affairs Medical Center, Long Beach, CA 90822.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|July 1, 1991
PubMed
Summary

Ascorbic acid supplements are necessary for patients on peritoneal dialysis, as they experience significant losses during treatment. Supplementation effectively restores plasma levels, indicating a clear need for these vitamin C interventions.

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Area of Science:

  • Nephrology
  • Nutritional Science
  • Biochemistry

Background:

  • Ascorbic acid (vitamin C) supplements are frequently given to end-stage renal disease patients undergoing peritoneal dialysis.
  • The necessity and impact of these supplements require further investigation.

Purpose of the Study:

  • To evaluate the need for ascorbic acid supplementation in chronic peritoneal dialysis patients.
  • To assess the effect of ascorbic acid and pyridoxine on plasma levels and dialysate removal.

Main Methods:

  • Seven chronic peritoneal dialysis patients were studied across three phases: no supplements, ascorbic acid, and ascorbic acid with pyridoxine.
  • Plasma ascorbic acid and pyridoxal-5-phosphate levels, along with dialysate removal rates, were measured.

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Main Results:

  • Plasma ascorbic acid levels decreased slightly in the supplement-free phase but increased significantly with supplementation (45% above baseline).
  • Ascorbic acid removal via dialysate increased by 57% with supplementation, while peritoneal clearance remained constant.
  • Pyridoxine supplementation did not affect plasma ascorbic acid levels.

Conclusions:

  • Ascorbic acid supplementation is crucial for maintaining adequate plasma levels in peritoneal dialysis patients due to significant dialysate losses.
  • The study confirms the need for vitamin C supplementation in this patient population.