Cerebral venous sinus thrombosis after gender reassignment surgery

Area of Science:

• Endocrinology
• Neurology
• Vascular Medicine

Background:

• Cerebral venous sinus thrombosis (CVT) has diverse etiologies, including head injury, cancer, infections, coagulopathies, pregnancy, autoimmune diseases, and dehydration.
• Estrogen therapy is a known risk factor for venous thromboembolism, but its specific role in CVT, particularly in transgender individuals, requires further investigation.

Observation:

• A case of cerebral venous sinus thrombosis (CVT) in a patient undergoing long-term feminizing genitoplasty and estrogen therapy is presented.
• The patient received approximately 15 years of estrogen therapy prior to CVT diagnosis.
• This represents a unique case, as similar instances have not been previously reported in medical literature.

Findings:

• The patient experienced a CVT event.
• Despite the CVT, the patient achieved an excellent clinical outcome.
• This case suggests a potential association between long-term estrogen therapy post-feminizing genitoplasty and CVT.

Implications:

• Further research is warranted to elucidate the specific risk factors contributing to long-term CVT in patients on estrogen therapy after feminizing genitoplasty.
• Understanding these risks is crucial for managing potential complications and optimizing patient care.
• This case underscores the importance of considering hormonal therapies in the differential diagnosis of CVT, especially in specific patient populations.