Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
Guijia He1, Dengfeng Dou, Liuqing Wei
1Department of Chemistry, Wichita State University, 206 McKinley Hall, 1845 Fairmount, Wichita, Kansas 67260, USA.
Abstract:
A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
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