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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Neuromyelitis optica associated with subacute human T-lymphotropic virus type 1 infection
Stéphane Olindo1, Mickaël Bonnan, Harold Merle
1Neurology Department, Centre Hospitalier Universitaire de Fort-de-France, Hôpital Pierre Zobda Quitman, BP 632, Fort-de-France 97261, Martinique, France. stephane.olindo@chu-fortdefrance.fr
Abstract:
Although human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy, or tropical spastic paraparesis (HAM/TSP), is usually considered as a progressive myelopathy, a subacute variant has been described. It is unusual for optic neuritis (ON) to be associated with an HTLV-1 infection. Neuromyelitis optica (NMO) is characterised by severe attacks of acute transverse myelitis and ON of unknown aetiology. We report a 61-year-old Afro-Caribbean male patient with subacute HAM/TSP associated with bilateral ON that occurred 5years previously. To our knowledge this is the first report of recurrent NMO syndrome associated with HTLV-1 infection.
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