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Published on: July 11, 2025
Anti-HIV and antiplasmodial activity of original flavonoid derivatives
Gilles Casano1, Aurélien Dumètre, Christophe Pannecouque
1Aix-Marseille Université, Institut des Sciences Moléculaires de Marseille, iSm2-UMR CNRS, Centre Saint Jérôme, Marseille Cedex 20, France.
Abstract:
In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial activity than flavonoids. Methoxyflavone 7e was the only one compound active in both P. falciparum and HIV-1 whereas aminomethoxyflavones showed activity against HIV-2. Para substitution on the B ring seemed to increase HIV-2 potency.
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