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Published on: September 20, 2019

Bovine colostrum in the management of nonorganic failure to thrive: a randomized clinical trial

Yunes Panahi1, Gholamhossein Falahi, Morteza Falahpour

  • 1Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran. yunespanahi@yahoo.com

Journal of Pediatric Gastroenterology and Nutrition
|July 20, 2010
PubMed

Insights

Oral bovine colostrum supplementation effectively improved weight gain in children with nonorganic failure to thrive (FTT). This 3-month intervention showed significant positive outcomes without reported side effects, offering a valuable addition to standard FTT management.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Clinical Research

Background:

  • Nonorganic failure to thrive (FTT) affects children's growth and development.
  • Effective management strategies for FTT are crucial for pediatric health.
  • Oral bovine colostrum is explored as a potential therapeutic agent.

Purpose of the Study:

  • To assess the clinical efficacy of oral bovine colostrum in managing nonorganic FTT in children.
  • To determine if bovine colostrum supplementation improves anthropometric indices in FTT patients.
  • To evaluate the safety and effectiveness of bovine colostrum as an adjunct therapy.

Main Methods:

  • A randomized clinical trial involving 120 children (1-10 years) with mild to moderate nonorganic FTT.
  • Participants were assigned to a control group (routine care) or a case group (routine care plus bovine colostrum 40 mg/kg/day for 3 months).
  • Growth was assessed using Gomez (weight for age) and Waterlow I (height for age) indices.

Main Results:

  • The bovine colostrum group showed a significantly higher mean Gomez index (81.72 vs 77.12, P=0.003) after 3 months.
  • A significantly greater proportion of children in the colostrum group achieved healthy status based on the Gomez index (20% vs 3.3%, P=0.006).
  • No significant difference was observed in the Waterlow I index between groups (P=0.094).

Conclusions:

  • Oral bovine colostrum supplementation is a safe and effective adjunct therapy for increasing weight in children with nonorganic FTT.
  • The 3-month supplementation period demonstrated significant improvements in weight gain.
  • Bovine colostrum offers a beneficial, side-effect-free option to enhance standard FTT treatments.
Abstract

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