[Neurological disorders in Alzheimer's disease]

Alzheimer's disease (AD) is the most frequent degenerative disease in the old age manifested itself mainly by the disturbances of cognitive functions. Motor disturbances develop in a significant number of patients as well, with the spectrum of their clinical manifestations and their impact on the level of functional disorders of patients remained less studied. The aim of the study was the evaluation of motor disorders in AD patients at different stages of the disease. Ninety patients with AD have been examined. Neurological disorders are identified in 79 (87.7%) patients including 17 (18.9%) patients with akinetic-rigid syndrome, 25 (27.8%) with primary walking disturbances and postural instability, 69 (76.6%) with pseudobulbar syndrome, 41 (45.6%) with stereotypy, 11 (12.2%) with pyramidal syndrome and 6 (6.7%) with epileptic seizures. The frequency of developing neurological disorders depended on age, duration and severity of dementia, concomitant hypertension, treatment with neuroleptics. Neurological syndromes were detected more frequently in patients with a predominance of attention and visual-spatial function disturbances.