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Updated: Jun 10, 2026
04:38
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
[Pathogenetic characteristics of post stroke affective disorders]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 20, 2010
Summary
Post-stroke affective disorders, including depression and anxiety, are linked to early platelet serotonin (PS) levels. Low PS levels within three days of a cerebral stroke may predict delayed emotional complications.
Area of Science:
- Neuroscience
- Psychiatry
- Biochemistry
Context:
- Cerebral stroke frequently leads to affective disorders.
- Understanding the biological markers associated with these disorders is crucial for timely intervention.
Purpose:
- To investigate the relationship between platelet serotonin (PS) levels and the development of affective disorders following a first cerebral stroke.
- To identify potential risk factors for post-stroke affective disorders.
Summary:
- Fifty patients with post-stroke affective disorders were studied, including depressions, anxiety disorders, and pseudo-depressions.
- Platelet serotonin (PS) levels were measured in the acute phase (first three days) and at day 28 post-stroke.
- Early PS levels and their changes correlate with affective disorder development, while lesion localization impacts anxiety-depressive disorders.
- Low initial PS levels may indicate a risk for delayed affective disorders.
Impact:
- Identifies early biological markers (PS levels) for predicting post-stroke affective disorders.
- Highlights the role of lesion localization in acute anxiety-depressive disorders.
- Provides insights for potential early diagnostic and therapeutic strategies in stroke recovery.
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