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Related Experiment Video

Updated: Jun 10, 2026

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

Self-noise-filtering phase-sensitive surface plasmon resonance biosensing.

Sergiy Patskovsky1, Michel Meunier, Paras N Prasad

  • 1Department of Engineering Physics, Ecole Polytechnique de Montréal, Case Postale 6079, succ. Centre-Ville, Montréal, Québec, H3C 3A7 Canada.

Optics Express
|July 20, 2010
PubMed
Summary
This summary is machine-generated.

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Phase-sensitive Surface Plasmon Resonance (SPR) biosensing noise is reduced using a novel polarimetry method. This self-noise-filtering technique enhances sensitivity for ultra-low detection limits in biosensing applications.

Area of Science:

  • Optics and Photonics
  • Biosensing Technology
  • Analytical Chemistry

Background:

  • Surface Plasmon Resonance (SPR) biosensing offers high sensitivity but is limited by instrumental noise.
  • Phase-sensitive SPR aims for ultra-low detection limits (10⁻⁸ RIU and lower), necessitating noise reduction.

Purpose of the Study:

  • To present a polarimetry-based methodology for efficient reduction of instrumental noises in phase-sensitive SPR measurements.
  • To enhance the sensitivity and lower the detection limit of phase-sensitive SPR biosensing.

Main Methods:

  • Employing a sinusoidal phase modulation of pumping light.
  • Selecting optimal modulation amplitude and phase relation for the first two modulation harmonics (F1 and F2).
  • Utilizing the difference signal (F1 - F2) to subtract amplitude drifts and double phase response.

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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Published on: November 23, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
07:39

Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons

Published on: July 21, 2018

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Main Results:

  • The proposed method achieves self-noise-filtering, inherently subtracting noise in each measurement.
  • Amplitude drifts from light source and optical element instabilities are effectively tackled.
  • The methodology enables drastic lowering of the detection limit even in simple, noisy experimental setups.

Conclusions:

  • The polarimetry-based approach significantly reduces instrumental noise in phase-sensitive SPR.
  • This self-noise-filtering technique is crucial for achieving the projected ultra-low detection limits in SPR biosensing.
  • The methodology offers a practical solution for enhancing SPR biosensor performance.