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Imaging of angiogenesis: from morphology to molecules and from bench to bedside

Ambros J Beer1, Xiaoyuan Chen

  • 1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. ambros.beer@tum.de

European Journal of Nuclear Medicine and Molecular Imaging
|July 20, 2010
PubMed
Abstract

No abstract available in PubMed .

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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