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Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal

Mei-Ching Yu1, Mei-Shiuan Yu, Meng-Kung Yu

  • 1Department of Pediatric Nephrology, Chang Gung Children's Hospital, Lin-Kou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan. yumeiching@gmail.com

Pediatric Nephrology (Berlin, Germany)
|July 20, 2010
PubMed

Insights

Acute poststreptococcal glomerulonephritis (APSGN) is linked to arterial stiffness. Persistently high arterial stiffness in APSGN patients may predict progression to chronic kidney disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Pediatrics

Background:

  • Acute poststreptococcal glomerulonephritis (APSGN) is a common postinfectious kidney disease.
  • Arterial stiffness is linked to inflammation, but its association with APSGN is unstudied.
  • Assessing arterial compliance in pediatric APSGN is crucial for understanding disease outcomes.

Purpose of the Study:

  • To evaluate brachial-ankle pulse wave velocity (baPWV) in pediatric APSGN patients.
  • To determine the predictive value of baPWV for APSGN outcomes.
  • To investigate arterial stiffness in children with APSGN.

Main Methods:

  • Measured baPWV in 16 children with APSGN, 11 with acute pyelonephritis (APN), and 25 healthy controls.
  • Conducted follow-up assessments of baPWV, blood pressure, and biochemical parameters in APSGN patients.
  • Analyzed baPWV changes over a 2-3 year follow-up period.

Main Results:

  • Children with APSGN showed significantly higher baPWV at diagnosis compared to APN and healthy groups (P<0.001).
  • baPWV normalized in most APSGN patients, but 2 boys had persistently elevated baPWV.
  • Persistent high baPWV correlated with proteinuria and progression to chronic kidney disease or end-stage renal disease.

Conclusions:

  • APSGN affects both the kidneys and peripheral arteries.
  • Acute arterial stiffness in APSGN may persist in patients who develop chronic kidney disease (CKD).
  • baPWV is a valuable tool for predicting long-term outcomes in pediatric APSGN.

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