Related Experiment Video
Updated: Jun 10, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Interpretation of 2002 Centers for Disease Control guidelines for group B streptococcus and evolving provider
Emma L Barber1, Edmund F Funai, Michael B Bracken
1Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Clinicians are altering labor management to achieve 4-hour intrapartum antibiotic prophylaxis for group B streptococcus (GBS)-positive women. This interpretation of 2002 CDC guidelines may lead to unintended consequences.
Area of Science:
- Obstetrics and Gynecology
- Infectious Disease Prevention
- Clinical Practice Guidelines
Background:
- Group B Streptococcus (GBS) poses risks during childbirth.
- Intrapartum antibiotic prophylaxis (IAP) is recommended for GBS-positive women.
- The 2002 Centers for Disease Control (CDC) guidelines provide recommendations for GBS prevention.
Purpose of the Study:
- To investigate clinician practices regarding IAP duration for GBS-positive women.
- To assess if clinicians alter labor management to meet the 4-hour IAP target.
- To understand the interpretation of 2002 CDC GBS guidelines in clinical practice.
Main Methods:
- A survey was administered to clinicians with labor floor privileges.
- The survey assessed interpretation and clinical application of the 2002 CDC GBS guidelines.
- Response rate was 72.9% (70 of 96 eligible clinicians).
Main Results:
- 77.1% of clinicians reported altering labor management when IAP was less than 4 hours.
- Alterations included delaying pushing, adjusting oxytocin, or modifying membrane rupture.
- Only 22.9% of clinicians did not alter management in such cases.
Conclusions:
- Clinicians are actively modifying labor management to achieve 4-hour IAP for GBS.
- Current clinical interpretations of the 2002 CDC guidelines may differ from intended recommendations.
- The clinical effects and outcomes of these management alterations are currently unknown.
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Standards of Care II
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...