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Serum glucose after intraperitoneal infusion of 5% dextrose solution
R M McNamara1, J M Schoffstall, R S Fuerst
1Department of Emergency Medicine, Medical College of Pennsylvania, Philadelphia 19129.
Annals of Emergency Medicine
|July 1, 1991
Summary
Intraperitoneal glucose infusion effectively treats hypoglycemia by rapidly increasing serum glucose levels. This study in rabbits demonstrates the viability of using the peritoneal cavity for glucose absorption.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Pharmacology
Background:
- Hypoglycemia is a critical condition requiring prompt glucose level normalization.
- Intraperitoneal (IP) administration is a potential route for therapeutic agent delivery.
Purpose of the Study:
- To investigate the efficacy of intraperitoneal glucose infusion as a treatment for hypoglycemia.
- To assess the rate and extent of glucose absorption from the peritoneal cavity into systemic circulation.
Main Methods:
- A randomized, placebo-controlled, crossover study was conducted on seven female New Zealand White rabbits.
- Animals received either no treatment (control), normal saline (placebo), or 5% dextrose solution via IP infusion.
- Serum glucose levels were monitored serially for 30 minutes post-intervention.
Main Results:
- Intraperitoneal glucose infusion led to significantly higher serum glucose levels compared to control and placebo groups starting at 10 minutes post-intervention.
- The mean increase in serum glucose at 30 minutes was 24% (34.7 mg/dL or 1.93 mmol/L) compared to the control group (P < .001).
- These findings indicate rapid absorption of glucose from the peritoneal cavity.
Conclusions:
- Intraperitoneal glucose administration is a rapidly absorbed and effective method for increasing systemic glucose levels.
- This route holds potential as a therapeutic strategy for managing hypoglycemia in relevant models.