Related Experiment Video
Updated: Jun 10, 2026

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells
Published on: October 4, 2013
The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue
Jose Manuel Rodríguez-Peña1, Raúl García, César Nombela
1Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), IRYCIS, 28040 Madrid, Spain.
Abstract:
Two mitogen-activated protein kinase (MAPK) pathways, viz. the high-osmolarity glycerol (HOG) and the cell wall integrity (CWI) pathways, regulate stress responses in the yeast Saccharomyces cerevisiae. Whereas the former is mainly involved in adaptation of yeast cells to hyperosmotic stress, the latter is activated under conditions leading to cell wall instability. Although MAPK signalling specificity can be conceived as requiring insulation of the different pathways, it is also becoming clear that the two pathways do not compete with each other but can be positively coordinated to regulate many stress responses. This review highlights our current knowledge about the collaboration between these two MAPK pathways to counteract different kinds of environmental stress.
Related Concept Videos
Yeast Signaling
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
MAPK Signaling Cascades
Cells Coordinate Growth and Proliferation
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
PI3K/mTOR/AKT Signaling Pathway

