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Corticosteroid therapy and respiratory muscle function in humans.

Y M Wang¹, T Zintel, A Vasquez

¹Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

The American Review of Respiratory Disease

|July 1, 1991

Summary

Prednisone, a common corticosteroid, does not significantly impact respiratory muscle strength or endurance in healthy individuals over a short-term, moderate-dose regimen. This study found no adverse effects on breathing muscles from prednisone treatment.

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Area of Science:

Pulmonology
Pharmacology
Human Physiology

Background:

Corticosteroids like prednisone are widely used for their anti-inflammatory properties.
Potential side effects on skeletal muscle function are a concern with corticosteroid use.
Respiratory muscles are crucial for ventilation and can be affected by systemic conditions and medications.

Purpose of the Study:

To investigate the short-term effects of prednisone administration on respiratory muscle function in healthy adults.
To determine if a moderate dose of prednisone impacts inspiratory and expiratory muscle strength and endurance.

Main Methods:

A double-blind, placebo-controlled study involving 16 healthy subjects.
Subjects were randomized to receive either 20 mg of prednisone daily or a placebo for two weeks.

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Respiratory muscle strength (Pimax, PEmax, Pdimax) and endurance were measured before and after the treatment period.

Main Results:

No statistically significant changes were observed in maximal inspiratory pressure (Pimax), maximal expiratory pressure (PEmax), or maximal diaphragmatic pressure (Pdimax) in the prednisone group.
Inspiratory muscle endurance also showed no significant change after prednisone treatment.
There were no significant differences in any respiratory muscle function parameters between the prednisone and placebo groups.

Conclusions:

Moderate-dose prednisone (20 mg daily) for two weeks does not appear to significantly impair respiratory muscle strength or endurance in healthy humans.
These findings suggest that short-term prednisone use at this dosage is unlikely to negatively affect respiratory muscle function in a healthy population.