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[Improving home auto-control in diabetic children: reducing atherogenic risk]
R Bayes García1, C Campoy Folgoso, E Pérez Bonilla
1Departamento de Pediatria, Facultad de Medicina, Universidad de Granada.
Insights
Optimizing home blood glucose monitoring in children with insulin-dependent diabetes mellitus (IDDM) improved metabolic control. This led to significant reductions in blood glucose, glycosilated serum protein, and glycosilated hemoglobin levels.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Cardiovascular Health
Context:
- Insulin-dependent Diabetes Mellitus (IDDM) in children presents significant risks for cardiovascular complications.
- Hyperlipidemia and hyperglycemia are key pathogenic factors in IDDM-related morbidity and mortality.
- Home self-management programs aim to mitigate frequent metabolic derangements.
Purpose:
- To assess the metabolic control status in pediatric IDDM patients undergoing optimized home self-monitoring.
- To investigate the relationship between metabolic control and plasma lipid profiles.
- To evaluate the impact of optimized home autocontrol on atherogenic ratios.
Summary:
- A study involved 49 pediatric IDDM patients, analyzing metabolic and lipid profiles before and after a 6-month home autocontrol optimization program.
- Key biochemical markers including glucose, glycosilated serum protein (GSP), and glycosilated hemoglobin (HbA1c) were measured.
- Results indicated that 65% of patients achieved favorable metabolic control, evidenced by significant decreases in Gly, GSP, and HbA1c levels.
Impact:
- Improved home autocontrol strategies can lead to better metabolic regulation in pediatric IDDM.
- Enhanced metabolic control may positively influence lipid profiles and reduce cardiovascular risk factors.
- This study highlights the effectiveness of structured home monitoring programs in managing pediatric diabetes.
Unlabelled:
Insulin-dependent Diabetes (IDDM) is a major endocrine abnormality in children and the greatest morbi-mortality problems for diabetic patients are those related to cardiovascular complications (macro-microangiopaties), where kept hyperlipidemia and hyperglucemia play a fundamental patogenic role. The programs for optimization of home autocontrol have reduced frequent metabolic derangements. The aim of this study was to analyze the metabolic control state and its relationships with plasma lipids and atherogenic ratios in diabetic patients that were submitted to a program for optimization of home autocontrol of this illness.
Material And Methods:
Blood samples were taken fom 49 IDDM, aged 10.53 +/- 0.51 (+/- SEM) years old, with a mean evolution period of 4.34 +/- 0.38 years, at the begining of the program (Stage I) and 6 months later (Stage II). Biochemical Analysis: Total Cholesterol (TC), cholesterol joined to high density lipoprotein (HDLc), Triglycerides (TG) and Phospholipids (Ph) were measured by microspectrphotometric methods. Cholesterol joined to very low and low density lipoproteins (VLDLc and LDLc, respectively) were calculated by Friedwald's formula. Apoproteins A and B (Apo A and Apo B) were measured using Mancini's method, Glycemia levels (Gly) by peroxidase's method, Glycosilated Serum Protein (GSP) by colormetric's method and Glycosilated haemoglobine (HbA1c) by chromatographic separation using cationic interchange microcolumns.
Results:
65% of the patients showed a significant decrease in plasma levels of Gly, GSP and HbA1c percentage between Stages I and II (Favourable Metabolic Control).(ABSTRACT TRUNCATED AT 250 WORDS)