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Updated: Jun 10, 2026

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
Published on: September 23, 2014
[Growth differentiation factor 15--a new marker in heart diseases]
Maciej Olechnicki1, Krzysztof Kasprzak, Aleksander Goch
110 Wojskowy Szpital Kliniczny z Poliklinik. w Bydgoszczy, Klinika Kardiologii, Oddział Kardiologii Inwazyjnej.
Abstract:
Growth differentiation factor-15 (GDF-15) is a cytokine with cardioprotective properties, which inhibits hypertrophy, cardiac remodeling and apoptosis. Participates in the life and cell death. The concentration of GDF-15 rapidly increases under the influence of ischemia-reperfusion damage to heart muscle, oxidative stress, inflammatory cytokines and pressure overload. In patients with acute coronary syndromes, heart failure and pulmonary embolism provides independent prognostic information, both short-and long-term. It is potentially a new marker of risk stratification in patients with heart disease and therapeutic decision making.
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