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Related Experiment Video

Updated: Jun 10, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Economic models in type 2 diabetes.

Y Yi¹, Z Philips, G Bergman

¹Mapi Values, Bollington, Macclesfield, UK.

Current Medical Research and Opinion

|July 21, 2010

Summary

This summary is machine-generated.

Cost-effectiveness models for type 2 diabetes (T2D) treatments often lack transparency in data synthesis and outcome selection. Future models should capture all relevant treatment effects, including side effects, for comprehensive evaluation.

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A Model of Chronic Nutrient Infusion in the Rat

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A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Area of Science:

Health economics
Pharmacoeconomics
Diabetes research

Background:

Economic evaluations are crucial for assessing novel type 2 diabetes (T2D) treatments.
Cost-effectiveness models (CEMs) guide treatment decisions but require critical appraisal.
Understanding the scope and limitations of existing T2D CEMs is essential.

Purpose of the Study:

To systematically identify and critically appraise CEMs for T2D treatments.
To assess the range of treatment effects captured by these models.
To identify areas for improvement in T2D economic modeling.

Main Methods:

Systematic literature search of databases (MEDLINE, EMBASE, etc.) and Health Technology Assessment (HTA) websites up to September 2008.
Extraction of model structure, data inputs/outputs, and appraisal of model quality using established criteria.
Identification of 20 distinct CEMs with multiple publications or associated evaluations.

Main Results:

Most T2D CEMs share a common fundamental structure and utilize similar micro-simulation techniques.
Transparency in data identification, synthesis, and outcome selection was frequently lacking.
Models varied in evaluated interventions and captured diabetes complications and adverse events; few included weight changes.

Conclusions:

Existing T2D CEMs, while numerous, often share common structural features.
Key limitations include a lack of transparency and the selective inclusion of outcomes.
Future CEMs should comprehensively incorporate all relevant treatment outcomes, including complications and side effects.