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Genomics

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Related Experiment Video

Updated: Jun 10, 2026

Novel Sequence Discovery by Subtractive Genomics

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Pig genome sequence--analysis and publication strategy.

Alan L Archibald, Lars Bolund, Carol Churcher

|July 21, 2010

Summary

This summary is machine-generated.

The Swine Genome Sequencing Consortium is sequencing the pig genome using a hybrid approach. Data is publicly available, with plans for further analysis and publication.

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Last Updated: Jun 10, 2026

Novel Sequence Discovery by Subtractive Genomics

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Area of Science:

Genomics
Comparative Genomics
Bioinformatics

Background:

The Swine Genome Sequencing Consortium (SGSC) is undertaking a comprehensive sequencing and characterization of the pig genome.
A hybrid sequencing strategy combining hierarchical shotgun sequencing of bacterial artificial chromosome (BAC) clones and whole genome shotgun (WGS) sequencing is employed.

Discussion:

The SGSC is releasing annotated genome assemblies (Sscrofa9, with Sscrofa10 under construction) via Ensembl browsers.
The upcoming Sscrofa10 assembly will integrate WGS data, achieving over 30x coverage using short Illumina/Solexa reads.
Sequence data is being released promptly to public repositories (Genbank/EMBL, NCBI/Ensembl) in accordance with international data-sharing agreements.

Key Insights:

Public accessibility of pig genome sequence data is prioritized.
The integration of WGS data is enhancing genome assembly quality and coverage.
Automated annotation pipelines (Pre-Ensembl, Ensembl) are utilized for genome characterization.

Outlook:

The SGSC outlines plans for the analysis, application, and publication of pig genome sequence results.
Future research will leverage the high-coverage WGS data for deeper genomic insights.
Continued collaboration and data sharing are central to advancing swine genomics.