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Related Concept Videos

Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Physiological Control of Respiration01:23

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 10, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Hypoxia modulates human eosinophil function.

Alon H Nissim Ben Efraim1, Ron Eliashar, Francesca Levi-Schaffer

  • 1Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. fls@cc.huji.ac.il.

Clinical and Molecular Allergy : CMA
|July 21, 2010
PubMed
Summary
This summary is machine-generated.

Hypoxia enhances eosinophil survival and pro-angiogenic functions, including VEGF release. This suggests a direct link between eosinophilic inflammation, hypoxia, and angiogenesis in allergic conditions.

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Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
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Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
05:17

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • Eosinophils play a role in allergic inflammation and angiogenesis.
  • Hypoxia is characteristic of inflamed tissues and may drive angiogenesis.
  • Eosinophils produce VEGF and are pro-angiogenic, but their direct link to hypoxia and angiogenesis in allergic inflammation is unclear.

Purpose of the Study:

  • To investigate eosinophil function and angiogenic potential under hypoxic conditions.

Main Methods:

  • Human peripheral blood eosinophils cultured in normoxic/hypoxic conditions.
  • Assessed viability, apoptosis, protein levels (Bcl-XL, Bax, HIF-1alpha), and MAPK phosphorylation.
  • Measured angiogenic mediator release (VEGF, IL-8) via ELISA.

Main Results:

  • Hypoxic eosinophils showed increased viability and anti-apoptotic protein levels.
  • Hypoxia elevated VEGF and IL-8 release, with high HIF-1alpha levels observed.
  • MAPK inhibitors reduced hypoxia-mediated VEGF release and HIF-1alpha expression.

Conclusions:

  • Eosinophils adapt to hypoxia by upregulating survival mechanisms.
  • Hypoxia enhances pro-angiogenic functions of eosinophils, including VEGF release.
  • Findings indicate a correlation between eosinophilic inflammation, hypoxia, and angiogenesis.