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Updated: Jun 10, 2026

Isolation and Culture of Primary Human Mammary Epithelial Cells
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Isolation and Culture of Primary Human Mammary Epithelial Cells

Published on: May 3, 2024

Granulomatous mastitis: a case series.

Shahida Parveen Afridi1, Aisha Memon, Aysha Memon

  • 1Department of General Surgery, Dow University of Health Sciences/Civil Hospital, Karachi. drshahishakeel@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 21, 2010
PubMed
Summary

Granulomatous mastitis (GM) is an uncommon inflammatory breast disease often mimicking tuberculosis or carcinoma. Early diagnosis and management, including steroids and antibiotics, are key for effective treatment and surveillance.

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Area of Science:

  • Breast pathology
  • Inflammatory diseases
  • Surgical oncology

Background:

  • Granulomatous mastitis (GM) is a rare, chronic inflammatory condition affecting the breast.
  • It typically presents in women of reproductive age, often non-lactating.
  • GM can clinically mimic other serious breast conditions such as tuberculosis and breast cancer.

Purpose of the Study:

  • To elucidate the clinical presentation and management strategies for granulomatous mastitis.
  • To differentiate GM from other breast pathologies based on clinical and diagnostic findings.
  • To evaluate treatment outcomes and recurrence rates in patients with GM.

Main Methods:

  • A retrospective case study of histopathologically diagnosed granulomatous mastitis.
  • Data collection included patient history, clinical examination, and diagnostic imaging (ultrasound, mammography, FNAC).

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  • Initial treatment involved antibiotics and corticosteroids, with surgical excision for recurrent cases.

    • Main Results:

    • The study included 22 patients with a mean age of 37.6 years; 82% were non-lactating.
    • Clinical presentations varied, including painful/painless lumps and discharging sinuses.
    • Differential diagnoses included chronic mastitis (40.9%), breast tuberculosis (36.3%), and malignancy (22.7%). Mammography was often inconclusive.

    Conclusions:

    • Granulomatous mastitis is an uncommon inflammatory breast disease with a clinical presentation that can mimic malignancy or tuberculosis.
    • While mammography may be non-conclusive, histopathology confirms the diagnosis.
    • Management involves a short course of steroids and antibiotics, with surgical excision for recurrent disease, alongside close surveillance.