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Related Experiment Video

Updated: Jun 10, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Adult ischemic necrotizing enterocolitis.

T Mitchell¹, E Christie, Habib Syed

¹Gastroenterology Unit, Warrington General Hospital, Cheshire, UK.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|July 21, 2010

Summary

This summary is machine-generated.

A myocardial infarction patient experienced unexplained rectal bleeding, ultimately diagnosed postmortem as necrotizing enterocolitis (NEC) caused by aortic thrombosis and bowel ischemia.

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Area of Science:

Gastroenterology
Cardiology
Pathology

Background:

Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition often seen in neonates, but rare in adults.
Adult NEC can be challenging to diagnose due to non-specific symptoms and rarity.

Observation:

A 66-year-old male with posterior myocardial infarction presented with painless lower gastrointestinal bleeding.
Despite extensive investigations, the source of bleeding remained unidentified during his hospitalization.

Findings:

Postmortem examination revealed severe atherosclerosis and aortic thrombosis leading to bowel ischemia, perforations, and necrosis.
These findings confirmed a diagnosis of necrotizing enterocolitis (NEC) in the adult patient.
Key NEC pathogenesis factors include bowel ischemia and bacterial infection.

Implications:

This case highlights the importance of considering rare causes of lower gastrointestinal bleeding in adults, even with concurrent cardiac events.
Severe atherosclerosis and aortic thrombosis can precipitate bowel ischemia and NEC.
Prompt diagnosis and management, ranging from supportive care to surgery, are crucial for NEC outcomes.