Related Experiment Video

Updated: Jun 10, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Adult ischemic necrotizing enterocolitis

T Mitchell1, E Christie, Habib Syed

  • 1Gastroenterology Unit, Warrington General Hospital, Cheshire, UK.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 21, 2010
PubMed

Insights

A myocardial infarction patient experienced unexplained rectal bleeding, ultimately diagnosed postmortem as necrotizing enterocolitis (NEC) caused by aortic thrombosis and bowel ischemia.

Area of Science:

  • Gastroenterology
  • Cardiology
  • Pathology

Background:

  • Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition often seen in neonates, but rare in adults.
  • Adult NEC can be challenging to diagnose due to non-specific symptoms and rarity.

Observation:

  • A 66-year-old male with posterior myocardial infarction presented with painless lower gastrointestinal bleeding.
  • Despite extensive investigations, the source of bleeding remained unidentified during his hospitalization.

Findings:

  • Postmortem examination revealed severe atherosclerosis and aortic thrombosis leading to bowel ischemia, perforations, and necrosis.
  • These findings confirmed a diagnosis of necrotizing enterocolitis (NEC) in the adult patient.
  • Key NEC pathogenesis factors include bowel ischemia and bacterial infection.

Implications:

  • This case highlights the importance of considering rare causes of lower gastrointestinal bleeding in adults, even with concurrent cardiac events.
  • Severe atherosclerosis and aortic thrombosis can precipitate bowel ischemia and NEC.
  • Prompt diagnosis and management, ranging from supportive care to surgery, are crucial for NEC outcomes.

More Related Videos

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...