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Related Experiment Video

Updated: Jun 10, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
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Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Published on: February 23, 2024

Psoriasis and multiple sclerosis: is there a link?

Tiffany Kwok1, Wei Jing Loo, Lyn Guenther

  • 1Schulich School of Medicine, University of Western Ontario, London, ON.

Journal of Cutaneous Medicine and Surgery
|July 21, 2010
PubMed
Summary
This summary is machine-generated.

Psoriasis and multiple sclerosis (MS) share some genetic links, involving T-helper 17 cells and IL23R polymorphisms. However, this review found no evidence that psoriasis is more common in MS patients or their families.

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Last Updated: Jun 10, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
08:17

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Published on: February 23, 2024

Area of Science:

  • Immunology
  • Neurology
  • Dermatology

Background:

  • Psoriasis and multiple sclerosis (MS) are autoimmune diseases mediated by T cells.
  • Previous case series suggested a potential association between psoriasis and MS.

Purpose of the Study:

  • To systematically review the literature and investigate the potential relationship between psoriasis and MS.
  • To explore shared genetic and immunological factors in both diseases.

Main Methods:

  • Systematic literature search of Medline, Cochrane Library, and EMBASE.
  • Review of studies examining the prevalence of psoriasis in MS cohorts and vice versa.

Main Results:

  • T-helper 17 cells and IL23R polymorphisms are implicated in the pathogenesis of both psoriasis and MS.
  • Reported prevalence of psoriasis in MS patients ranges from 0.41% to 7.7%.
  • Large-scale studies and analysis of MS patient families did not show an increased prevalence of psoriasis, despite some shared genetic factors.

Conclusions:

  • While common genetic factors exist, psoriasis is not demonstrably more prevalent in individuals with MS or their relatives.
  • Further research may be needed to clarify the complex interplay between these conditions.