Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing treatment for depressed parents of children with emotional and behavioral disorders: A multi-site feasibility trial.

PloS one·2026
Same author

Developmental predictors of suicide attempts from childhood to early adulthood: a 15-year prospective cohort study.

Lancet regional health. Americas·2026
Same author

Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone-Unexpected Modulation of Androgen Balance in Normal and Obese Rats.

Nutrients·2026
Same author

Depression, anxiety symptoms, and association with household characteristics in adolescent boys and girls from Matiari District, Pakistan: A community-based cross-sectional study.

PloS one·2026
Same author

Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm.

Nutrients·2026
Same author

Letter to the Editor: 'Key links between autistic characteristics and anxiety symptoms in autistic children and youth': a response to Lai et al. (2026).

Child and adolescent mental health·2026

Related Experiment Video

Updated: Jun 10, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Autism spectrum disorders and epigenetics.

Daria Grafodatskaya1, Brian Chung, Peter Szatmari

  • 1Hospital for Sick Children, Toronto, Ontario, Canada.

Journal of the American Academy of Child and Adolescent Psychiatry
|July 21, 2010
PubMed
Summary

Epigenetic dysregulation plays a significant role in the development of autism spectrum disorders (ASD), integrating genetic and environmental factors. This review explores how epigenetic modifications influence neurodevelopmental processes in ASD etiology.

More Related Videos

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Autism spectrum disorders (ASD) are complex neurodevelopmental conditions with multifactorial causes.
  • Both genetic predisposition and environmental exposures are implicated in ASD etiology.
  • Epigenetic mechanisms, which alter gene expression without changing DNA sequence, are increasingly recognized as a crucial link between genes and environment in ASD.

Purpose of the Study:

  • To review and illustrate the role of epigenetic modifications in the etiology of autism spectrum disorders.
  • To highlight how epigenetic changes may integrate genetic and environmental influences on neurodevelopment in ASD.

Main Methods:

  • Systematic review of current research on epigenetic modifications in ASD.
  • Summarization of knowledge regarding genes and genomic regions with abnormal epigenetic regulation in ASD.
  • Discussion of the etiologic role of environmental factors in ASD development and epigenetic dysregulation.

Main Results:

  • Epigenetic dysregulation is observed in genetic syndromes commonly comorbid with ASD, such as Rett and Fragile X syndromes.
  • Abnormal epigenetic regulation is associated with both syndromic (e.g., 15q11-13 maternal duplication) and nonsyndromic forms of ASD.
  • Environmental factors linked to ASD development also show associations with epigenetic dysregulation.

Conclusions:

  • Epigenetic dysregulation is consistently associated with the development of autism spectrum disorders.
  • The findings support a significant role for epigenetics in the complex, multifactorial etiology of ASD.
  • Epigenetic mechanisms offer a potential pathway for understanding gene-environment interactions in ASD.