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Related Experiment Video

Updated: Jun 10, 2026

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
14:33

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species

Published on: August 30, 2012

Switching DISC1 function in neurogenesis: Dixdc1 selects DISC1 binding partners.

Takashi Namba1, Kozo Kaibuchi

  • 1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.

Developmental Cell
|July 21, 2010
PubMed
Summary

Disrupted-in-schizophrenia 1 (DISC1) and Dixdc1 proteins control embryonic neurogenesis by differentially regulating neural stem cell proliferation and migration. This finding offers new insights into brain development and schizophrenia pathogenesis.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • The schizophrenia-associated gene DISC1 plays a critical role in regulating neurogenesis, a complex process involving the generation and development of neurons.
  • Understanding the precise molecular mechanisms by which DISC1 influences neurogenesis is crucial for deciphering its role in brain development and psychiatric disorders.

Discussion:

  • Singh et al. investigated the distinct roles of DISC1 and its interacting partner Dixdc1 in regulating neural stem cell proliferation and migration during embryonic development.
  • The study reveals differential regulation of cell proliferation and migration by DISC1 and Dixdc1, highlighting a complex interplay in neurogenesis.

Key Insights:

  • DISC1 and Dixdc1 exhibit distinct functional mechanisms in controlling cell proliferation and migration.

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Last Updated: Jun 10, 2026

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  • These proteins are essential for proper embryonic neurogenesis, impacting neuronal development pathways.

    • Outlook:

    • Further research into DISC1 and Dixdc1 functions may uncover novel therapeutic targets for neurodevelopmental disorders like schizophrenia.
    • Elucidating these molecular pathways can advance our understanding of the genetic underpinnings of complex brain disorders.