Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Self-Help Support Groups

Self-Help Support Groups

Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.

BMJ open·2026

Same author

Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center.

Alcohol, clinical & experimental research·2025

Same author

Early Online: Vol. 114 No. 4.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024

Same author

Deletion of NADPH oxidase 2 in chondrocytes exacerbates ethanol-mediated growth plate disruption in mice without major effects on bone architecture or gene expression.

Alcohol, clinical & experimental research·2023

Same author

Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2023

Same author

Testing reprise.

British dental journal·2020

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

e-Infrastructures supporting research into depression, self-harm and suicide.

S McCafferty¹, T Doherty, R O Sinnott

¹National e-Science Centre, University of Glasgow, Glasgow G12 8QQ, UK.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences

|July 21, 2010

Summary

This summary is machine-generated.

This study explores enhancing research on depression, self-harm, and suicide using e-Science. It addresses challenges in managing distributed data for sensitive mental health research.

More Related Videos

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

Area of Science:

Social Sciences
Computer Science
Mental Health Research

Background:

Research on depression, self-harm, and suicide is crucial for public health.
Existing research infrastructures face challenges in managing distributed and heterogeneous data.
The Economic and Social Research Council (ESRC)-funded Data Management through e-Social Sciences (DAMES) project aims to address these issues.

Purpose of the Study:

To investigate how e-Science infrastructures and techniques can enhance research on depression, self-harm, and suicide.
To explore the challenges in supporting research infrastructures for sensitive data.
To describe the necessary distributed and heterogeneous datasets for such research.

Main Methods:

Exploration of challenges in supporting research infrastructures.
Description of distributed and heterogeneous datasets.
Application and demonstration of an advanced user and security-driven infrastructure.

Main Results:

Identification of key challenges in data management for sensitive mental health research.
Characterization of distributed and heterogeneous datasets required.
Demonstration of a functional user and security-driven infrastructure tailored for this research.

Conclusions:

Advanced user and security-driven infrastructures are essential for supporting sensitive mental health research.
Addressing data management challenges through e-Science can enhance research on depression, self-harm, and suicide.
The developed infrastructure provides a robust solution for provisioning distributed and heterogeneous datasets.