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Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
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Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation
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The Virtual Physiological Human ToolKit.

Jonathan Cooper1, Frederic Cervenansky, Gianni De Fabritiis

  • 1Oxford University Computing Laboratory, Wolfson Building, Parks Road, Oxford OX1 3QD, UK. jonathan.cooper@comlab.ox.ac.uk

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|July 21, 2010
PubMed
Summary
This summary is machine-generated.

The Virtual Physiological Human (VPH) initiative developed a VPH ToolKit, a flexible toolbox of interoperable technologies and standards for personalized healthcare. An online VPH resource facilitates access to these tools, methods, and services for researchers.

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Area of Science:

  • Computational biology
  • Medical informatics
  • Bioinformatics

Background:

  • The Virtual Physiological Human (VPH) is a European e-Science initiative focused on patient-specific computer models for personalized and predictive healthcare.
  • The VPH Network of Excellence (VPH-NoE) project aims to foster collaboration and address common challenges within VPH research.
  • A critical need exists for accessible and integrated tools, methodologies, and services to advance VPH research.

Purpose of the Study:

  • To create a VPH ToolKit, conceptualized as a "toolbox" of interoperable technologies and standards, rather than a monolithic entity.
  • To establish an online resource for the VPH community to disseminate and discover available tools, methods, and services.
  • To enhance the sustainability and accessibility of VPH research infrastructure across Europe.

Main Methods:

  • Development of a "toolbox" approach for the VPH ToolKit, emphasizing modularity and interaction around common standards.
  • Creation of an online database to catalog VPH research tools, methodologies, and services.
  • Implementation of a web front-end for the database, enabling searching, contribution, and feedback.

Main Results:

  • The VPH ToolKit is designed as a collection of interacting technologies and methodologies, not a single integrated system.
  • An online VPH resource (database with web front-end) has been established to serve the VPH research community.
  • The resource supports searching, adding/updating entries, and user feedback, promoting community contribution.

Conclusions:

  • A flexible, standards-based "toolbox" approach is essential for the VPH ToolKit due to the field's diversity.
  • The online VPH resource effectively addresses the need for dissemination and discovery of VPH research tools and services.
  • Community contribution is encouraged to ensure the ongoing development and utility of the VPH ToolKit and its associated resources.