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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

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Related Experiment Video

Updated: Jun 10, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Tumor-host interactions: a far-reaching relationship.

Sandra S McAllister1, Robert A Weinberg

  • 1Harvard Medical School, 1 Blackfan Circle, Karp Research Building, Room 5-214, Boston, MA 02115, USA smcallister1@partners.org

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 21, 2010
PubMed
Summary

Cancer progression involves complex interactions between tumor cells and their local and distant host environments. Understanding these tumor-host relationships is crucial for developing effective cancer therapies.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

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Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Carcinomas comprise neoplastic epithelial cells and a tumor stroma, including mesenchymal cells and extracellular matrix.
  • Tumor-associated stromal cells actively promote cancer progression through interactions with carcinoma cells.
  • Tumor-host interactions extend beyond the local microenvironment, affecting distant organs.

Purpose of the Study:

  • To review recent advances in understanding local and systemic environments in cancer progression.
  • To explore the capacity of tumors to perturb the host environment.
  • To discuss therapeutic strategies targeting tumor-host interactions.

Main Methods:

  • Literature review of recent advances in cancer biology and tumor-host interactions.
  • Analysis of studies on local and systemic effects of tumors on the host.
  • Synthesis of current therapeutic approaches targeting tumor-host relationships.

Main Results:

  • Tumor progression is influenced by both local stromal components and systemic host interactions.
  • Tumors actively modulate distant host organs, impacting overall cancer biology.
  • Fragmentary understanding of these complex local and systemic interactions currently exists.

Conclusions:

  • A comprehensive understanding of both local and systemic tumor-host interactions is essential for explaining cancer biology.
  • Disrupting tumor-host relationships represents a promising therapeutic strategy.
  • Further research is needed to fully elucidate and target these complex interactions.