Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to 'Population pharmacokinetics-based recommendations for a single delayed or missed dose of nusinersen': Neuromuscular Disorders 31 (2021) 310-318/doi: 10.1016/j.nmd.2021.02.014.

Neuromuscular disorders : NMD·2022

Same author

Startle responses in Duchenne muscular dystrophy: a novel biomarker of brain dystrophin deficiency.

Brain : a journal of neurology·2022

Same author

Evolution of bulbar function in spinal muscular atrophy type 1 treated with nusinersen.

Developmental medicine and child neurology·2022

Same author

Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy.

Journal of cachexia, sarcopenia and muscle·2022

Same author

Restoration of Nusinersen Levels Following Treatment Interruption in People With Spinal Muscular Atrophy: Simulations Based on a Population Pharmacokinetic Model.

CNS drugs·2022

Same author

Growth pattern trajectories in boys with Duchenne muscular dystrophy.

Orphanet journal of rare diseases·2022

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Published on: April 8, 2014

Are human and mouse satellite cells really the same?

Luisa Boldrin¹, Francesco Muntoni, Jennifer E Morgan

¹Dubowitz Neuromuscular Centre, UCL Institute of Child Health, 30 Guilford Street, London WC1N1EH, United Kingdom. l.boldrin@ich.ucl.ac.uk

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

|July 21, 2010

Summary

This summary is machine-generated.

Human satellite cells are muscle stem cells, similar to mouse satellite cells, crucial for muscle repair and regeneration. Further research is needed to understand human satellite cells and their niche.

More Related Videos

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

Published on: July 20, 2015

An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells

An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells

Published on: July 7, 2023

Related Experiment Videos

Last Updated: Jun 10, 2026

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Published on: April 8, 2014

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles

Published on: July 20, 2015

An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells

An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells

Published on: July 7, 2023

Area of Science:

Muscle biology
Stem cell research
Regenerative medicine

Background:

Satellite cells are quiescent cells crucial for skeletal muscle regeneration.
Mouse satellite cells are well-characterized muscle stem cells.
Human skeletal muscle regeneration implies a similar role for human satellite cells.

Purpose of the Study:

To compare human and mouse satellite cells.
To identify similarities and differences between human and mouse satellite cells.
To highlight knowledge gaps in human satellite cell research.

Main Methods:

Literature review comparing human and mouse satellite cells.
Discussion of current knowledge and research gaps.
Suggestions for future research directions.

Main Results:

Human and mouse satellite cells share similarities as muscle stem cells.
Differences exist between human and mouse satellite cells that require further investigation.
Significant knowledge gaps remain regarding human satellite cell function and regulation.

Conclusions:

Human satellite cells are likely muscle stem cells, analogous to their mouse counterparts.
Further research is essential to fully elucidate the characteristics and behavior of human satellite cells.
Developing new markers and in vitro models of the human satellite cell niche are key future directions.