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Related Experiment Video

Updated: Jun 10, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
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Brain tumor headaches: from bedside to bench.

Philippe Goffaux1, David Fortin

  • 1Department of Neurosurgery and Neuro-oncology, Université de Sherbrooke, Faculty of Medicine, Sherbrooke, Québec, Canada. Philippe.Goffaux@USherbrooke.ca

Neurosurgery
|July 21, 2010
PubMed
Summary

Headaches can indicate brain tumors, but the link isn't always clear. This review explores brain tumor headaches, their causes, and why pain may persist after treatment.

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Area of Science:

  • Neurology
  • Oncology
  • Pain Medicine

Background:

  • Headache is a common symptom, but its association with brain tumors is complex and not fully understood.
  • While up to 60% of brain tumor patients report headaches, some with large tumors experience no pain, complicating diagnosis.
  • Understanding the tumor-headache relationship is crucial for early detection and effective management of central nervous system neoplasms.

Purpose of the Study:

  • To review over 80 years of research on brain tumor headaches.
  • To delineate the relationship between tumor characteristics (location, laterality, growth rate) and headache pain.
  • To propose new etiological models involving neuronal sensitization and explain persistent pain post-treatment.

Main Methods:

  • Comprehensive literature review of studies on brain tumor headaches.

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Last Updated: Jun 10, 2026

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  • Analysis of the association between tumor attributes and headache presentation.
  • Examination of current etiological theories and proposed new models.

    • Main Results:

    • Headaches are a frequent symptom in brain tumor patients, but their absence does not rule out a tumor.
    • Tumor location, laterality, and growth rate influence headache characteristics.
    • Peripheral and central sensitization of neurons are implicated in neoplastic headache pain.

    Conclusions:

    • The tumor-headache link is variable, necessitating careful clinical evaluation.
    • New models of neuronal sensitization may explain persistent pain even after tumor debulking.
    • Further research is needed to refine understanding and improve patient outcomes for brain tumor-related headaches.