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Updated: Jun 10, 2026

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid
Published on: March 8, 2024
Life-threatening reversible acidosis caused by alcohol abuse
Philip D Shull1, Jayson Rapoport
1Department of Nephrology & Hypertension, Kaplan Medical Center, Rehovot 76100, Israel.
Background:
A 52-year-old man with a history of alcohol dependency was admitted to the emergency room with life-threatening anion gap metabolic acidosis. He admitted to drinking large quantities of alcohol during the previous day.
Investigations:
Physical examination, blood and urine analyses, including calculation of his anion gap and plasma osmolal gap, and measurement of serum alcohol levels.
Diagnosis:
Severe but rapidly reversible lactic acidosis and associated alcohol-induced ketoacidosis.
Management:
Intravenous thiamine, intravenous fluids and bicarbonate.
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