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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Related Experiment Video

Updated: Jun 10, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Multimodal drug delivery using gold nanoparticles.

Chae-kyu Kim1, Partha Ghosh, Vincent M Rotello

  • 1Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

Nanoscale
|July 21, 2010
PubMed
Summary
This summary is machine-generated.

Gold nanoparticles (AuNPs) offer a versatile platform for drug delivery due to their biocompatibility and tunable properties. This review explores strategies leveraging AuNPs as nanocarriers for enhanced therapeutic applications.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Gold nanoparticles (AuNPs) are increasingly recognized for their potential in nanomedicine.
  • Their synthesis is straightforward, and they exhibit excellent biocompatibility and low toxicity.
  • Surface functionalization allows for tailored properties and targeted delivery.

Purpose of the Study:

  • To review strategies for utilizing gold nanoparticles in drug delivery.
  • To highlight the advantages of AuNPs as nanocarriers.
  • To discuss the versatility and tunability of AuNP properties for therapeutic applications.

Main Methods:

  • Literature review of existing research on gold nanoparticles for drug delivery.
  • Analysis of chemical and physical properties of AuNPs relevant to drug encapsulation and release.
  • Discussion of various functionalization and delivery strategies.

Main Results:

  • Gold nanoparticles demonstrate facile synthesis and ease of functionalization.
  • Their unique monolayer properties offer versatile delivery methods and tunable surface characteristics.
  • AuNPs present inherent biocompatibility and non-toxicity, making them suitable for therapeutic use.

Conclusions:

  • Gold nanoparticles are highly promising nanocarriers for drug delivery systems.
  • Their adaptable nature allows for diverse therapeutic applications.
  • Further research into AuNP-based drug delivery strategies is warranted.