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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Understudied clinical dimensions in pediatric obsessive compulsive disorder
Adam B Lewin1, Nicole Caporino, Tanya K Murphy
1Department of Pediatrics, Rothman Center for Neuropsychiatry, University of South Florida College of Medicine, 800 Sixth Street South, Saint Petersburg, FL 33701, USA. alewin@health.usf.edu
This study found that insight, avoidance, and indecisiveness in youth with Obsessive-compulsive disorder (OCD) impact functional impairment. Treatment for OCD reduced these symptoms, suggesting these factors are key targets for therapy.
Area of Science:
- Child and Adolescent Psychiatry
- Behavioral Science
- Clinical Psychology
Background:
- Insight, avoidance, indecisiveness, overvalued responsibility, pervasive slowness, and pathological doubting are key aspects of Obsessive-compulsive disorder (OCD) presentation in youth.
- These factors are understudied yet crucial for understanding OCD's clinical picture and treatment response.
Purpose of the Study:
- To evaluate the phenomenology and treatment sensitivity of specific OCD-related constructs in youth.
- To assess the utility of ancillary items on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) for measuring these constructs.
Main Methods:
- Eighty-nine youth diagnosed with OCD completed the CY-BOCS with six subsidiary items.
- Participants also underwent assessments for OCD symptom clusters, comorbid symptoms (depression, anxiety), behavioral problems, and functional impairment.
Main Results:
- Low insight, significant avoidance, indecisiveness, pervasive slowness, and excessive responsibility correlated with higher functional impairment.
- Clinical improvement in OCD severity was associated with decreased avoidance, doubting, and sense of responsibility.
Conclusions:
- The six ancillary CY-BOCS items provide a practical and valid measure of constructs linked to treatment outcomes in youth with OCD.
- These findings have implications for clinical practice, guiding therapeutic targets for cognitive-behavioral therapy (CBT) in pediatric OCD.
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