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Related Experiment Video

Updated: Jun 10, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Screening coagulation testing using the APTT: which reagent to choose?

Francine R Dembitzer, Yvelisse Suarez, Louis M Aledort

    American Journal of Hematology
    |July 21, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Activated partial thromboplastin time (APTT) testing can be difficult to interpret. Using both sensitive and insensitive reagents for APTT testing helps quickly rule out factor deficiencies and improves patient management.

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    Area of Science:

    • Clinical pathology
    • Hematology
    • Diagnostic laboratory science

    Background:

    • Activated partial thromboplastin time (APTT) is a cornerstone of hemostasis testing.
    • Interpreting prolonged APTT results can be challenging due to reagent sensitivity to lupus anticoagulants.

    Observation:

    • Prolonged APTT results often necessitate further testing for factor deficiencies and lupus anticoagulants.
    • This can lead to delays in patient diagnosis and management.

    Findings:

    • Employing both lupus anticoagulant-sensitive and insensitive APTT reagents facilitates rapid exclusion of significant factor deficiencies.
    • This dual-reagent approach streamlines the diagnostic process.

    Implications:

    • This strategy can reduce unnecessary laboratory investigations and expedite patient care.
    • It highlights the importance of selecting appropriate APTT reagents based on clinical needs.
    • Fosters essential communication between laboratory professionals and clinicians regarding optimal APTT testing protocols.