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Updated: Jun 10, 2026
09:41
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
Lipins: multifunctional lipid metabolism proteins
1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Annual Review of Nutrition
|July 22, 2010
Summary
Lipin proteins are key regulators of lipid metabolism and gene expression. Genetic variations in lipin genes are linked to metabolic diseases like obesity and diabetes.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Lipin proteins are conserved across eukaryotes and play crucial roles in lipid metabolism.
- They exhibit dual functions: phosphatidate phosphatase activity in lipid biosynthesis and transcriptional coactivator activity in metabolic gene regulation.
Purpose of the Study:
- To review key findings on lipin protein functions in metabolic homeostasis.
- To examine the role of lipin genes in rare and common human metabolic diseases.
Main Methods:
- Literature review of studies in yeast, mouse, and human models.
- Analysis of genetic variations in lipin genes and their association with metabolic disorders.
Main Results:
- Lipin proteins are central to triglyceride and phospholipid biosynthesis via the glycerol-3-phosphate pathway.
- Mammalian lipins regulate metabolic gene expression, impacting overall metabolic homeostasis.
- Genetic variations in lipin genes are associated with obesity, hyperinsulinemia, hypertension, and type 2 diabetes.
Conclusions:
- Lipin proteins are critical regulators of cellular and organismal metabolism.
- Dysregulation of lipin function and genetic variations contribute to metabolic diseases, highlighting their therapeutic potential.
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