Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Studies of the Energy Dependence of Diboson Polarization Fractions and the Radiation-Amplitude-Zero Effect in WZ Production with the ATLAS Detector.

Physical review letters·2024
Same author

Combination of Searches for Higgs Boson Pair Production in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2024
Same author

Automatic segmentation of high-risk clinical target volume and organs at risk in brachytherapy of cervical cancer with a convolutional neural network.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

Statistical Combination of ATLAS Run 2 Searches for Charginos and Neutralinos at the LHC.

Physical review letters·2024
Same author

Combination of Measurements of the Top Quark Mass from Data Collected by the ATLAS and CMS Experiments at sqrt[s]=7 and 8 TeV.

Physical review letters·2024
Same author

Burden of gastrointestinal cancers among people younger than 50 years in China, 1990 to 2019.

Public health·2024
Same journal

Can Neuroscience Inform Peacebuilding?

The European journal of neuroscience·2026
Same journal

Game-Based Foreign-Language Speech Rehearsal Improves Pitch Processing Beyond Speech Domain.

The European journal of neuroscience·2026
Same journal

Sleep Oscillations Across Cortical, Subcortical and Cerebellar Structures in Magnetoencephalography.

The European journal of neuroscience·2026
Same journal

Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology.

The European journal of neuroscience·2026
Same journal

Cognitive Flexibility and Bilingual Language Switching: An fMRI Meta-Analysis.

The European journal of neuroscience·2026
Same journal

Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.

The European journal of neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

AMPA receptor trafficking and learning.

J Keifer1, Z Zheng

  • 1Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USA. jkeifer@usd.edu

The European Journal of Neuroscience
|July 22, 2010
PubMed
Summary
This summary is machine-generated.

AMPA receptor trafficking dynamically alters synaptic strength, providing a cellular basis for learning and memory. Impaired trafficking is linked to cognitive deficits in Alzheimer's disease.

More Related Videos

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons
06:18

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons

Published on: April 3, 2014

Related Experiment Videos

Last Updated: Jun 10, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons
06:18

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons

Published on: April 3, 2014

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Cognitive Science

Background:

  • AMPA-type glutamate receptors (AMPARs) undergo rapid synaptic transport.
  • This dynamic trafficking influences synaptic plasticity, learning, and memory.

Purpose of the Study:

  • To review evidence linking AMPAR trafficking to learned responses.
  • To explore AMPAR trafficking's role in Alzheimer's disease-related cognitive dysfunction.

Main Methods:

  • Summary of behavioral and cellular studies on AMPAR trafficking.
  • Review of research on synaptic dysfunction in Alzheimer's disease.

Main Results:

  • AMPAR trafficking is a key mechanism for various learned behaviors.
  • Impaired AMPAR trafficking contributes to learning and memory deficits in Alzheimer's disease.

Conclusions:

  • Multistage AMPAR trafficking occurs during learning.
  • Investigating all AMPAR subunits is crucial for understanding learning mechanisms.