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Related Experiment Video

Updated: Jun 10, 2026

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

Small artery remodelling in diabetes.

Enrico Agabiti Rosei¹, Damiano Rizzoni

¹Department of Medical and Surgical Sciences, University of Brescia, Clinica Medica, Brescia, Italy.

Journal of Cellular and Molecular Medicine

|July 22, 2010

Summary

Diabetic patients with hypertension experience microvascular structural changes. Renin-angiotensin system blockade effectively reverses these vascular alterations, improving outcomes.

Area of Science:

Cardiovascular Medicine
Endocrinology
Nephrology

Background:

Structural changes in systemic vasculature are a consequence of hypertension.
Non-insulin-dependent diabetes mellitus is associated with hypertrophic remodeling of small arteries.
Microvascular alterations are key in diabetes-related organ damage and clinical events.

Purpose of the Study:

To review data on microvessel structural changes in diabetes mellitus.
To assess the potential for effective treatment to correct these vascular alterations.
To evaluate the role of renin-angiotensin system blockade in managing microvascular changes.

Main Methods:

Review of available data on microvessel structure in diabetic patients.
Analysis of the impact of antihypertensive treatments on vascular remodeling.

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Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

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Last Updated: Jun 10, 2026

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Murine Spinotrapezius Model to Assess the Impact of Arteriolar Ligation on Microvascular Function and Remodeling

Published on: March 3, 2013

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

Focus on drugs targeting the renin-angiotensin system (ACE inhibitors, ARBs).

Main Results:

Hypertension leads to vascular remodeling, characterized by smaller lumen and unchanged wall size in essential hypertension.
Hypertrophic remodeling of subcutaneous small arteries is observed in non-insulin-dependent diabetes mellitus.
Drugs blocking the renin-angiotensin system significantly regress structural alterations in small resistance arteries of diabetic hypertensive patients.

Conclusions:

Microvascular structural changes are common in diabetes and contribute to organ damage.
The tunica media to internal lumen ratio is a significant prognostic index in hypertensive and diabetic patients.
Renin-angiotensin system blockade demonstrates efficacy in preventing and reversing microvascular structural alterations.