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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jun 10, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

[Association between thyroiditis and cancer. Our experience].

D Vendettuoli1, G Di Rocco, G Patrizi

  • 1Dipartimento di Scienze Chirurgiche, Sapienza Universitá di Roma, Italy.

Il Giornale Di Chirurgia
|July 22, 2010
PubMed
Summary

Thyroid cancer and autoimmune thyroiditis association was observed in 18.6% of 671 patients undergoing total thyroidectomy. This highlights the link between inflammatory environments and papillary carcinoma, suggesting molecular marker research for prevention.

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Context:

  • Total thyroidectomy is a common surgical procedure for various thyroid pathologies.
  • The co-occurrence of autoimmune thyroid disease and thyroid cancer is documented but warrants further investigation.
  • Understanding the interplay between inflammation and thyroid cancer development is crucial for effective prevention strategies.

Purpose:

  • To investigate the association between thyroiditis and thyroid cancer in a cohort of patients undergoing total thyroidectomy.
  • To explore the prevalence of thyroiditis in patients with thyroid cancer.
  • To examine the potential role of the RET/PTC genetic background in papillary thyroid carcinoma within an inflammatory environment.

Summary:

  • A retrospective analysis of 671 patients who underwent total thyroidectomy revealed a significant association between thyroiditis and thyroid cancer, observed in 18.6% of cases.
  • The study identified a higher prevalence of the RET/PTC genetic rearrangement in papillary thyroid carcinoma cases associated with an inflammatory thyroid environment.
  • These findings highlight the complex relationship between autoimmune processes, genetic factors, and thyroid malignancy.

Impact:

  • The results underscore the importance of considering autoimmune thyroid conditions in the context of thyroid cancer.
  • Identifying specific molecular markers targeting inflammatory pathways could lead to novel strategies for thyroid cancer prevention.
  • This research contributes to a deeper understanding of thyroid cancer etiology and potential therapeutic targets.