Related Experiment Video
Updated: Jun 10, 2026
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
[Long-term survival of high-risk kidney transplant patients]
Yun Miao1, Li-xin Yu, Wen-feng Deng
1Department of Organ Transplantation, Nan Fang Hospital, Southern Medical University, Guangzhou, China.
Insights
This study on high-risk kidney transplant patients found that immunological risks negatively impact survival. Reducing acute rejection and complications is crucial for long-term success in non-immunological high-risk groups.
Area of Science:
- Nephrology and Immunology
- Transplantation Science
Context:
- Kidney transplantation is a vital treatment for end-stage renal disease.
- Identifying and managing high-risk patient groups is essential for optimizing outcomes.
- This study analyzes outcomes in various high-risk renal transplant categories.
Purpose:
- To evaluate patient and graft survival rates in high-risk renal transplant recipients.
- To compare incidences of acute rejection, chronic rejection, and complications.
- To determine factors influencing long-term success in these patient groups.
Summary:
- 921 high-risk kidney transplant recipients (pediatric, retransplant, highly sensitized, elderly, diabetic, HBV/HCV) were compared to 807 controls.
- Lower patient/graft survival observed in retransplant, highly sensitized, and HBV/HCV groups.
- Increased acute rejection in pediatric and highly sensitized groups; more complications in elderly, diabetic, and HBV/HCV groups.
Impact:
- Highlights the importance of managing immunological risks for better long-term renal transplant outcomes.
- Suggests that reducing complication rates is key for non-immunological high-risk recipients.
- Provides insights for tailoring strategies to improve survival in diverse high-risk kidney transplant populations.
Objective:
To summarize the experiences in high-risk renal transplant recipients for ketter long-term survival.
Methods:
From April 1991 to December 2008, a total of 921 kidney recipients with high-risk factors were divided into six groups as following: (1) pediatric patients (< 18 years old) (GI, n = 34); (2) retransplant recipients (GII, n = 169); (3) high sensitized patients (PRA> 30% or peak PRA > 50%)(GIII, n = 35); (4) elderly recipients (> 60 years old) (GIV, n = 297); (5) diabetic patients (GV, n = 112); (6) patients with HBV/HCV infection or HBV/HCV carrier (GVI, n = 274). Each group was compared to a control of 807 recipients without any above risk factor for patient and graft survival at 1, 3 and 5 years. Incidences of acute rejection (AR), chronic rejection (CR) and complication were analyzed and compared respectively between the studied subjects and the control group as well.
Results:
Compared with the control group, patient/graft survivals were lower in GII, GIII and GVI (all P < 0.05), GIV had worse patient survival (P < 0.05); AR and CR incidences were greater in GI and GIII (all P < 0.05); GIV, GV and GVI had more complications.
Conclusions:
This study suggests the benefits for long-term outcome in high-immunological risk renal transplant recipients of low acute selection incidence rate, and reduction of complication incidences is the key to long term results for non-immunological high risk recipients.
Related Concept Videos
01:28Kidney Transplant I: Introduction
01:26Kidney Transplant II: Surgical Procedure
01:16Kidney Transplant III: Nursing Management
01:29Acute Kidney Injury III: Clinical Manifestations
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:28Chronic Kidney Disease III: Interprofessional Care