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[Prognostic importance of abnormal glucose metabolism in chronic heart failure]

Jing-chuan Guo1, Zhao-ping Li, Wei Gao

  • 1Department of Cardiology, Peking University Third Hospital, Key Laboratory of Ministry of Education on Molecular Cardiology, Beijing 100191, China.

Zhonghua Yi Xue Za Zhi
|July 22, 2010
PubMed

Insights

Diabetes mellitus independently predicts 1-year mortality in chronic heart failure (CHF) patients. Impaired fasting glucose (IFG) and higher fasting plasma glucose (FPG) levels also increase mortality risk in CHF patients without diabetes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Context:

  • Chronic heart failure (CHF) affects millions globally, with abnormal glucose metabolism being a common comorbidity.
  • Understanding the prognostic implications of glucose dysregulation in CHF is crucial for risk stratification and management.
  • Previous studies have explored the link between diabetes and adverse outcomes in CHF, but the role of pre-diabetic states like impaired fasting glucose (IFG) requires further elucidation.

Purpose:

  • To investigate the prognostic significance of abnormal glucose metabolism, including diabetes mellitus and IFG, on 1-year all-cause mortality in patients with decompensated chronic heart failure (CHF).
  • To determine whether IFG and fasting plasma glucose (FPG) levels are associated with increased mortality risk in CHF patients without diagnosed diabetes.
  • To identify independent predictors of mortality within the CHF population based on glucose metabolism status.

Summary:

  • A cohort of 444 decompensated CHF patients was analyzed, categorized into diabetic (34.5%), IFG (25.4%), and normal glucose (40.1%) groups.
  • One-year all-cause mortality was significantly higher in patients with diabetes mellitus and IFG compared to those with normal glucose levels (P < 0.01).
  • Diabetes mellitus was identified as an independent predictor of 1-year mortality (OR = 2.383). In non-diabetic CHF patients, IFG (OR = 3.564) and higher FPG levels (OR = 1.791) were associated with increased 1-year mortality.

Impact:

  • This study highlights that abnormal glucose metabolism, including both diagnosed diabetes and pre-diabetic states (IFG), significantly impacts mortality risk in patients with chronic heart failure.
  • The findings underscore the importance of screening for and managing glucose abnormalities in CHF patients, even in the absence of overt diabetes.
  • Identifying IFG as an independent risk factor in non-diabetic CHF patients provides a target for early intervention to potentially improve outcomes.
Abstract

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