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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Classification of proximal endovenous closure levels and treatment algorithm
Peter F Lawrence1, Ankur Chandra, Michael Wu
1Division of Vascular Surgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095-6908, USA. pflawrence@mednet.ucla.edu
A new classification system helps manage thrombus extension after endovenous closure of saphenous veins. A short course of anticoagulation effectively retracts thrombus, with larger vein diameter and prior deep venous thrombosis (DVT) increasing extension risk.
Area of Science:
- Vascular Surgery
- Phlebology
- Interventional Radiology
Background:
- Endovenous closure is a standard treatment for saphenous vein incompetence.
- Thrombus extension above the closure site, near the epigastric or femoral vein, can occur.
- A standardized system is needed to guide management of such events.
Purpose of the Study:
- To introduce a novel six-tier classification system for saphenous endovenous closure.
- To establish an algorithm for patient management based on the classification.
- To evaluate the system's utility in guiding therapy after endovenous treatment.
Main Methods:
- A six-tier classification system was developed based on thrombus proximity to the epigastric or femoral vein.
- An algorithm for treatment was applied to all patients undergoing radio-frequency ablation.
- Data from 500 consecutive patients were analyzed.
Main Results:
- Radio-frequency ablation achieved successful closure in 99.6% of patients.
- Thirteen patients (2.6%) experienced thrombus bulging into the femoral vein, treated with anticoagulation.
- Anticoagulation led to thrombus retraction in all cases within an average of 16 days, with no instances of femoral deep venous thrombosis (DVT).
- Higher rates of proximal thrombus extension were observed in patients with a history of DVT and great saphenous vein (GSV) diameter >8 mm.
Conclusions:
- The developed classification system aids in managing saphenous endovenous closure complications.
- GSV diameter >8 mm and a history of DVT are significant risk factors for proximal thrombus extension.
- A short course of low-molecular-weight heparin (LMWH) is effective for thrombus retraction.
- Management of thrombus flush with the femoral vein wall requires further definition but generally has a benign outcome.
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