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Published on: September 27, 2024
Spondyloarthropathies: an independent cardiovascular risk factor?
Sylvain Mathieu1, Pascal Motreff, Martin Soubrier
1Service de rhumatologie, CHU Gabriel-Montpied, 58, rue Montalembert, 63003 Clermont-Ferrand, France. smathieu11@yahoo.fr
Insights
Patients with spondyloarthropathies face higher cardiovascular disease risks due to chronic inflammation and common risk factors. Effective management involves controlling disease activity and addressing these conventional risks.
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Rheumatoid arthritis patients show increased cardiovascular mortality and morbidity.
- Data on cardiovascular risk in spondyloarthropathies are limited.
- Spondyloarthropathies encompass a group of inflammatory joint diseases.
Purpose of the Study:
- To review and synthesize evidence on cardiovascular disease risk in spondyloarthropathies.
- To identify contributing factors to elevated cardiovascular risk in this population.
- To outline recommendations for cardiovascular risk management.
Main Methods:
- Literature review of published studies.
- Analysis of factors contributing to cardiovascular risk.
- Synthesis of current understanding of disease mechanisms.
Main Results:
- Patients with spondyloarthropathies exhibit an increased risk of cardiovascular disease.
- This excess risk is multifactorial, driven by chronic systemic inflammation.
- High prevalence of conventional cardiovascular risk factors further contributes to the risk.
Conclusions:
- Optimal cardiovascular risk management in spondyloarthropathies requires integrated strategies.
- Controlling disease activity is crucial for mitigating cardiovascular risk.
- Targeting conventional cardiovascular risk factors is essential for comprehensive patient care.
Abstract:
An increase in cardiovascular mortality and morbidity has been convincingly documented in rheumatoid arthritis. Data on spondyloarthropathies are more limited. Here, we discuss published studies indicating that patients with spondyloarthropathies are at increased risk for cardiovascular disease. The excess risk is probably multifactorial, being related both to chronic systemic inflammation and to high prevalences of conventional cardiovascular risk factors. Cardiovascular risk management in patients with spondyloarthropathies requires optimal control of disease activity combined with interventions targeting conventional cardiovascular risk factors.
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