A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26

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Jeffrey C Phillips1, Luis Lembcke, Tamara Chamberlin

  • 1College of Veterinary Medicine, Department of Small Animal Clinical Sciences, 2407 River Drive, C247 Veterinary Teaching Hospital, Knoxville, TN 37996-4544, USA. jphill35@utk.edu

Genomics
|July 22, 2010
PubMed

Insights

Researchers identified a specific gene linked to bone cancer in Scottish Deerhounds. This discovery offers new insights into osteosarcoma genetics in both dogs and humans, advancing cancer research.

Area of Science:

  • Comparative Oncology
  • Canine Genetics
  • Cancer Genomics

Background:

  • Spontaneous canine tumors closely mimic human cancers in clinical and molecular aspects.
  • Scottish Deerhounds, a giant breed, have a high incidence of bone cancer (osteosarcoma).
  • Previous studies suggested a major gene influences osteosarcoma in this breed.

Purpose of the Study:

  • To investigate the genetic basis of osteosarcoma in Scottish Deerhounds using a whole genome mapping approach.
  • To identify specific genetic loci linked to the osteosarcoma phenotype in a large pedigree.

Main Methods:

  • Utilized a whole genome mapping strategy.
  • Analyzed a four-generation pedigree of Scottish Deerhounds exhibiting osteosarcoma.
  • Evaluated linkage between the osteosarcoma phenotype and genetic markers.

Main Results:

  • Found significant evidence of linkage (Zmax=5.766) between osteosarcoma and markers on Canine Chromosome 34 (CFA34).
  • This region on CFA34 is syntenic to human chromosome 3q26.
  • Identified a novel locus associated with osteosarcoma susceptibility.

Conclusions:

  • A specific genetic locus on CFA34 is strongly associated with osteosarcoma in Scottish Deerhounds.
  • This finding provides critical insights into the genetic underpinnings of osteosarcoma in canines.
  • The identified locus may also inform our understanding of human osteosarcoma genetics due to conserved synteny.

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