Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In situ three-dimensional printing for reparative and regenerative therapy.

Biomedical microdevices·2019

Same author

A Perspective on 3D Bioprinting in Tissue Regeneration.

Bio-design and manufacturing·2019

Same author

Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels.

Science advances·2019

Same author

Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering.

ACS nano·2019

Same author

A Microfabricated Sandwiching Assay for Nanoliter and High-Throughput Biomarker Screening.

Small (Weinheim an der Bergstrasse, Germany)·2019

Same author

A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.

Biofabrication·2019

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Cell-adhesive and mechanically tunable glucose-based biodegradable hydrogels.

Hyeongho Shin¹, Jason W Nichol, Ali Khademhosseini

¹Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Acta Biomaterialia

|July 22, 2010

Summary

Researchers developed a new biodegradable hydrogel from glucose and malic acid. This tunable poly(glucose malate)methacrylate (PGMma) material shows promise for tissue engineering and cell culture applications.

More Related Videos

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Regenerative Medicine

Background:

Hydrogels are crucial biomaterials for regenerative medicine due to their tissue-mimicking water content.
Developing materials with tunable mechanical and biological properties is essential for advanced tissue engineering.

Purpose of the Study:

To synthesize and characterize a novel hydrophilic, biodegradable, and photocrosslinkable polymer, poly(glucose malate)methacrylate (PGMma).
To evaluate the mechanical properties, degradation rates, and cell-adhesion capabilities of PGMma hydrogels for potential biomedical applications.

Main Methods:

Synthesis of poly(glucose malate)methacrylate (PGMma) by incorporating methacrylate groups into a polymer of glucose and malic acid.
Tuning hydrogel properties by adjusting reactant ratios, degree of methacrylation, and polymer concentration.
Characterization of hydrogel mechanical properties (compressive modulus, strain at failure), hydration, and degradation rates.
Assessment of cell adhesion and spreading on PGMma hydrogels.

Main Results:

PGMma hydrogels exhibited tunable compressive moduli (1.8–172.7 kPa) and hydration (18.7–114.1%).
The hydrogels demonstrated a range of degradation rates and supported cell adhesion and spreading.
Mechanical and degradation properties could be modulated by synthesis parameters.

Conclusions:

A new class of biodegradable, cell-adhesive, and mechanically tunable glucose-based hydrogels (PGMma) has been developed.
These PGMma hydrogels offer versatile properties suitable for diverse tissue engineering and cell culture applications.
The biomimetic nature and tunable characteristics position PGMma as a promising material for regenerative medicine.