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Cerebral distribution of white matter lesions in migraine with aura patients

G Rossato1, A Adami, V N Thijs

  • 1Sacro Cuore Hospital, Italy.

Cephalalgia : an International Journal of Headache
|July 22, 2010
PubMed
Abstract

Insights

Migraine aura symptoms do not affect the location of white matter lesions (WMLs) in the brain. This study found no association between aura type and WML distribution in migraine patients.

Area of Science:

  • Neurology
  • Neuroimaging
  • Migraine Research

Background:

  • Migraine with aura (MA) is a neurological disorder.
  • White matter lesions (WMLs) are frequently observed in MA patients.
  • The relationship between specific aura symptoms and WML distribution is not well understood.

Purpose of the Study:

  • To investigate the cerebral distribution of WMLs in migraine patients.
  • To compare WML distribution based on different types of aura symptoms.

Main Methods:

  • 185 migraine with aura patients were enrolled in the Shunt-Associated Migraine (SAM) study.
  • Aura symptoms were classified (visual, sensory, aphasic, motor, vertebrobasilar).
  • MRI scans (T2-weighted, FLAIR) were analyzed for WMLs using Fazekas and Schelten's scales.

Main Results:

  • The majority of patients experienced visual aura (99%).
  • Deep white matter lesions (D-WMLs) were predominantly found in the frontal lobes (86%).
  • No significant association was found between the type of aura symptom and the presence or location of WMLs.

Conclusions:

  • Aura symptoms do not appear to influence the cerebral distribution of WMLs in migraine.
  • Further research may explore other factors contributing to WMLs in MA.

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