Thyroid function and internal carotid artery stenosis in ischemic stroke.
Seul-Ki Jeong1, Jin-Young Seo, Hae-Sung Nam
1Department of Neurology and Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, South Korea. jeongsk@jbnu.ac.kr
Endocrine Journal
|July 22, 2010
Summary
Subclinical thyroid disease is common in ischemic stroke patients. Low-normal free thyroxine levels are linked to a higher risk of internal carotid artery steno-occlusion.
Area of Science:
- Neurology
- Endocrinology
- Vascular Medicine
Background:
- Thyroid dysfunction is linked to vascular events.
- Internal carotid artery steno-occlusion (ICS) is a risk factor for ischemic stroke.
Purpose of the Study:
- Determine the prevalence of subclinical thyroid disease in ischemic stroke patients.
- Investigate the association between normal thyroid function ranges and ICS.
Main Methods:
- Analyzed 382 ischemic stroke patients.
- Defined ICS as >50% internal carotid artery narrowing.
- Classified normal free thyroxine (fT4) into low-normal, mid-normal, and high-normal groups.
Main Results:
- Prevalence of subclinical hypothyroidism was 4.5%, subclinical hyperthyroidism was 1.6%.
- Low-normal fT4 group showed a significantly higher percentage of ICS.
- Low-normal fT4 was independently associated with increased ICS risk (OR 2.80).
Conclusions:
- Subclinical thyroid disease prevalence is similar to the general population.
- Low-normal thyroid function is an independent risk factor for ICS in euthyroid ischemic stroke patients.
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