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[Oral molecular targeting agents in hematological malignancy]

Shihoko Wakabayashi1, Kazuteru Ohashi

  • 1Department of Hematology, Tokyo Metropolitan Infectious Disease Center Komagome Hospital, Tokyo, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 22, 2010
PubMed

Insights

Molecular targeted therapies offer promising treatments for blood cancers like chronic myeloid leukemia (CML), acute promyelocytic leukemia (APL), and multiple myeloma (MM). New drugs provide effective options for patients with resistant or relapsed conditions.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Context:

  • Molecular targeted therapy represents a significant advancement in treating hematological malignancies.
  • Chronic myeloid leukemia (CML) management has been revolutionized by imatinib, with long-term data showing high efficacy and tolerability.
  • Alternative therapies like dasatinib and nilotinib are available for imatinib-resistant cases.

Purpose:

  • To provide a comprehensive review of current molecular targeted therapies for CML, APL, and MM.
  • To present data supporting the efficacy of these targeted treatments.
  • To highlight advancements in managing hematological malignancies through molecular approaches.

Summary:

  • Imatinib is the standard for chronic-phase CML, with second-generation inhibitors available for resistance.
  • Acute promyelocytic leukemia (APL) treatment has shifted to differentiation therapy, combining all-trans retinoic acid (ATRA) with chemotherapy.
  • Thalidomide and lenalidomide offer new treatment avenues for multiple myeloma (MM), including relapsed/refractory cases.

Impact:

  • Molecular targeted therapies have improved long-term outcomes and quality of life for patients with CML, APL, and MM.
  • The development of targeted agents signifies a paradigm shift from conventional chemotherapy to precision medicine in hematologic oncology.
  • This review underscores the growing importance and success of molecularly-driven treatment strategies in combating blood cancers.

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